Cushing (2) syndrome (angle tumor syndrome; cerebellopontine angle syndrome; pontocerebellar angle tumor syndrome; acoustic neuroma syndrome)  336

General: Tumor involving cranial nerves V, VI, VII, and VIII and brainstem; occurs between ages 30 and 45 years.

Ocular: Paresis orbicularis muscle (VII); paresis external rectus muscle (VI); mixed nystagmus with head tilt; palsies of extraocular muscles are accounted for by increased intracranial pressure if the aqueduct of Sylvius is closed by the growing tumor; decreased corneal reflex V (homolateral and early sign); bilateral papilledema (increased intracranial pressure).

Clinical: Deafness (homolateral); labyrinth function disturbed or lost; tinnitus; hyperesthesia of the face; homolateral facial nerve paresis (total paralysis rare); hoarseness; difficulties in swallowing; unilateral limb ataxia; gait ataxia; nuchal headache; emesis; facial pain, numbness and paresis; progressive unilateral hearing loss.

Berg EF. The ocular signs and symptoms of posterior fossa disorders. In: Gay AJ, Burde RM, eds. Clinical Concepts in Neuro-Ophthalmology. Int Ophthalmol Clin

Cushing H. Tumors of the nevus acusticus. Philadelphia: WB Saunders, 1917.