Erb-goldflam syndrome (erb ii syndrome; hoppe-goldflam disease; pseudoparalytic syndrome; myasthenia gravis)

General: Occurs at any age; more frequent between ages 20 and 40 years; more females affected than males; progressive; spontaneous; symptoms improve or resolve with rest in early stages of disease (see Myasthenia Gravis, Neonatal or Infantile); caused by autoantibodies against the acetylcholine receptor at the neuromuscular junction, leading to abnormal fatigability and weakness of skeletal muscle.

Ocular: Transient diplopia; ptosis of upper eyelids.

Clinical: Excessive fatigability of musculature; symptoms appear and increase as day progresses; expressionless face; sagging jaw; difficulty in chewing and talking; nasal regurgitation.

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