Isotretinoin Teratogen Syndrome
General: Maternal ingestion of isotretin 212d38c oin (Accutane) during early pregnancy.
Ocular: Small palpebral fissures; deep orbits; systemic treatment with isotretinoin has been associated with blepharitis and conjunctivitis.
Clinical: Prominent forehead; low-set, small, undifferentiated ears; depressed nasal bridge; small chin.
Benke PJ. Isotretmoin teratogen syndrome. JAMA 1984; 24:3267-3269.
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