Leukemia

General: Acute or chronic blood disorder.

Ocular: Engorgement of conjunctival vessels; papillary hypertrophy; aggregations of tumor cells in conjunctiva, choroid, and orbit; secondary glaucoma; retinal venous engorgement and tortuosity with pronounced constrictions; retinal hemorrhages; retinal detachment; cotton-wool spots; macular edema; papilledema; optic atrophy; optic neuritis; paralysis of extraocular muscles; hypopyon; vitreous opacities; retinal sea fans; perilimbal subconjunctival infiltrates; corneal leukemic infiltration (rare); shallow serous retinal detachments; hyphema; iris neovascularization; central retinal vein occlusion; vitreous infiltrates.

Clinical: Frequent involvement of central nervous system; intracranial hemorrhage; thrombocytopenia; rising white cell count.

Brown GC, et al. Leukemic optic neuropathy. Int Ophthalmol 1981; 3:11-l6.

Currie JN, et al. Optic neuropathy in chronic lymphocytic leukemia. Arch Ophthalmol 1988; 106:654-660.

Font RL, et al. Acute monocytic leukemia recurring as bilateral perilimbal infiltrates. Ophthalmology 1985; 92:1681-l685.

Leveille AS, Morse PH. Platelet-induced retinal neovasculanzation in leukemia. Am J Ophthalmol 1981; 91:640-644.

Murtha TJ. Hematologic disorders: leukemia, dysproteinemia, and anemia. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. IV. Philadelphia: WB Saunders, 1994:2986.

Robb RM, et al. A pathological study of eye involvement in acute leukemia of childhood. Trans Am Ophthalmol Soc 1978; 76:90-l01.

Rodgers R, et al. Ocular involvement in congenital leukemia. Am J Ophthalmol 1986; 101:730-732.

Swartz M, Schumann GB. Acute leukemic infiltration of the vitreous diagnosed by pars a aspiration. Am J Ophthalmol 1980; 90:326-330.