Lewis syndrome (tuberoserpiginous syphilid of lewis)

General: Lesions more common on nose and ears but may involve eyelids primarily; clinical manifestations are similar to lupus vulgaris.

Ocular: Lesions most frequently involve the lower eyelids; tear ducts may become involved, with lesions of mouth and nose as a direct extension or via the lymphatic route; granulomatous conjunctival lesions, usually an extension of involvement of buccal and nasal mucosa; iridocyclitis may occur; corneal ulcers as seen in tuberculous granulomatosis.

Clinical: Skin lesions similar to those of the face may be seen on other parts of extremities or trunk.

Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.

Magalini SI, Scrascia E. Dictionary of Medical Syndromes, 2^nd ed. Philadelphia: JB Lippincott, 1981.