Mucocutaneous lymph node syndrome (mln syndrome; kawasaki disease)

General: Multisystem syndrome with worldwide distribution; occurs from age 2 months\ to 9 years; increased in 111b12b cidence in summer; etiology unknown, but allergic reactions to chemicals or abnormal reactions to numerous infections have been suggested.

Ocular: Severe conjunctival congestion and hyperemia (88%); uveitis; dacryocystitis; anterior uveitis (commonly bilateral); punctate keratitis.

Clinical: Fever (1 to 2 weeks; does not respond to antibiotics) 'strawberry tongue'; red palms and soles; indurative edema; membranous desquamation from fingertips; polymorphous exanthema; arthritis; myocarditis; enlarged cervical lymph nodes.

Bums JC, et al. Anterior uveitis associated with Kawasaki syndrome. Pediatr Infect Dis 1985; 4:258-261.

Kawasaki T, et al. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics 1974; 54:271.

Mauriello JA, et al. Dacryocystitis following Kawasaki's disease. Ophthal Plast Reconstr Surg 1986; 2:209.

Naoe S, et al. Kawasaki disease, with particular emphasis on arterial lesions. Acta Pathol Jpn 1991; 41:785-790.

Puglise JV, et al. Ocular features of Kawasaki's disease. Arch Ophthalmol 1982; 100:1101-l103.

Raimer SS, Sanchez RL. Vasculitis in children. Semin Dermatol 1992; 11:48-56.