Mycosis fungoides syndrome (szary syndrome; malignant cutaneous reticulosis syndrome)

General: Lymphoma characterized by abnormal lymphocytes having hyperchromatic, hyperconvolu 646j98g ted nuclei; malignant, cutaneous T-cell lymphoma, which initially presents as a nonspecific erythematous cutaneous eruption that progresses to form plaques and tumors.

Ocular: Thick and swollen eyelids; ectropion; blepharitis; loss of eyelashes; keratoconjunctivitis; uveitis; retinal edema and exudates; papilledema; exophthalmos; retinal hemorrhage; endophthalmitis; pupillary dilatation; scleritis; corneal opacity; optic disk swelling.

Clinical: Pruritus followed by thickening and edema of the skin; dermatitis exfoliativa; eczema; pyoderma; pigmentary changes of body and extremities (mottled appearance); hyperhidrosis.

Deutsch AR, Duckworth JK. Mycosis fungoides of upper lid. Am J Ophthalmol 1968; 65:884-888.

Forester HC. Mycosis fungoides with intraocular involvement. Trans Am Acad Ophthalmol Otolaryngol 1960; 64:308.

Fraunfelder FT, Roy FT. Current Ocular Therapy, 5th ed. Philadelphia: WB Saunders, 2000.

Leitch, R. J, et al. Ocular involvement in mycosis fungoides. Br J Ophthalmol 1993; 77: 126-l27.

Meekins B, et al. Cutaneous T-cell lymphoma presenting as a rapidly enlarging ocular adnexal tumor. Ophthalmology 1985; 92:1288-l293.