Neonatal Hemolytic Disease of Hyperbilirubinemia (Kernicterus; Bilirubin Encephalopathy)
General: Condition with severe neural symptoms associated with high levels of bilirub 454e41e in in the blood.
Ocular: Disturbance of supranuclear vertical gaze; mild ocular motility defects; involuntary levator palpebrae inhibition.
Clinical: Athetosis; hearing loss; possible central nervous system (CNS) damage, characterized by deep yellow staining of the basal nuclei, globus pallidus, putamen and caudate nucleus, cerebellar and bulbar nuclei, and gray substance of the cerebrum.
Aramideh M, et al. Abnormal eye movements in blepharospasm and involuntary levator palpebrae inhibition. Clinical and pathophysiological considerations. Brain 1994; 117[Part 6]:1457-l474.
Hoyt CS, et al. The supranuclear disturbances of gaze in kernicterus. Ann Ophthalmol 1978; 10:1487-l492.
Hyman CB, et al. CNS abnormalities after neonatal hemolytic disease of hyperbilirubinemia. Am J Dis Child 1969; 117:395.
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