Oculo-orogenital syndrome (riboflavin deficiency syndrome; gopalan ii syndrome; jolliffe syndrome)

General: Vitamin B deficiency and possible vitamin A deficiency; prognosis good with diet therapy.

Ocular: Conjunctivitis, varying from mild to severe; keratitis; optic atrophy; corneal vascularization.

Clinical: Stomatitis; glossitis; scrotal dermatitis with pruritus, erythema, erythema of pharynx and soft palate; small sensitive ulcers of buccal membranes; diarrhea; fatigue; muscular weakness; painful feet with erythema, exfoliation, and ulceration; burning; itching; mental depression; dizziness; oral mucosa becomes pale and macerated with fissuring of skin.

Bajart AM. Lid inflammations. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. 1. Philadelphia: WB Saunders, 1994:114.

Bloom SM, et al. Nutritional amblyopia in American prisoners. Am J Ophthalmol 1946; 29: 1248.

Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.

Jacobs EC. Oculo-oro-genital syndrome: a deficiency disease. Ann Intern Med

McLaren DS. Cutaneous changes in nutritional disorders. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al., eds. Dermatology in general medicine, 3rd ed. New York: McGraw-Hill, 1987:1601-l613.