Postvaccinial ocular syndrome

General: Immediate contamination and inoculation 121f52b or as a delayed reaction; incubation time 3 days.

Ocular: Orbital cellulitis; pustules and vesicles on the eyelids (vesicles appear grayish with purulent discharge); lids swollen and red with swelling of preauricular and postauricular lymph nodes; ophthalmoplegia; mild anterior uveitis; conjunctival and corneal vesicles similar to the lid lesions; corneal marginal ulcers (eventually may lead to corneal perforation and loss of the eye); chorioretinitis (occasionally); central serous retinopathy; central retinal vein thrombosis; panophthalmitis; neuritis; ocular vaccinia may mimic signs of herpes simplex virus, varicella-zoster virus, and acanthamoeba keratitis.

Clinical: Postvaccinial encephalitis; severe local purulent skin reaction; severe headache; fever; malaise.

Jones BR, Al-Hussaini MK. Therapeutic considerations in ocular vaccinia. Trans Ophthalmol Soc UK 1963; 83:613.

Lee SF, et al. Vaccinia keratouveitis manifesting as a masquerade syndrome. Am J Ophthalmol 1994; 117:480-487.

Rosen E. A postvaccinial syndrome. Am J Ophthalmol 1948; 31:1443-l453.