Prader-willi syndrome (prader-labhart-willi-fanconi syndrome; h20 syndrome; hypogenital dystrophy with diabetic tendency; hypotonia-hypomentia-hypogonadism-obesity [hhho] syndrome; royer syndrome)

General: Etiology unknown; dominant inheritance is suspected; predominantly seen in males; Royer syndrome is Prader-Willi syndrome associated with diabetes mellitus; nongenetic condition characterized by infantile hypotonia, hypogonadism, and obesity.

Ocular: Strabismus; ocular hypertelorism; myopia; exotropia; glaucoma; cataracts; congenital ocular fibrosis syndrome; diabetic retinopathy.

Clinical: Mental retardation; short stature; muscular hypotonia; small hands and feet; obesity; cryptorchidism; hypogonadism; dental caries; clinodactyly; partial syndactyly of toes and fingers.

Libov AJ, Maino DM. Prader-Willi syndrome. J Am Optom Assoc 1994; 65:355-359.

Magalini SI, Scrascia E. Dictionary of Medical Syndromes. 2nd ed. Philadelphia: JB Lippincott, 1981.

Prader W, et al. Eli Syndrome von Adipositas, Kleinwuchs, Kryptorchismus and Oligophrenia nach myatonieartigem Zustand im Neuge-borenenalter. Schweiz Med Wochenschr 1956; 86:1260-l261.