Primary Antiphospholipid Syndrome (PAS)
General: Thrombophilic disorder characterized by the presence of autoantibo 929j99j dies and CNS involvement, venous thrombosis, and ocular manifestations.
Ocular: Visual disturbances (visual obscurations, amaurosis fugax, diplopia, homonymous field defects, and scintillating scotoma due to migraine); two forms of retinopathy: cotton-wool spots with or without hemorrhages and vasoocclusive ocular disease.
Clinical: Many patients will experience CNS involvement in the form of either a stroke or a transient ischemic attack; visual disturbances are largely due to CNS rather than ocular ischemia.
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Dahlback B. Resistance to activated protein C caused by the factor V R 506Q mutation is a common risk factor for venous thrombosis. Thromb Haemost 1997; 78:483-488.
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Glacet-Bernard A, et al. Antiphospholipid antibodies in retinal vascular occlusions: a prospective study of 75 patients. Arch Ophthalmol 1994; 112:790-795.
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