Pseudoexfoliation syndrome

General: Prevalent over age 70 years; rare before age 40 years; 252g63c unilateral involvement in 40% to 50% of cases; asymmetry of severity in bilateral cases; most common in Caucasians, especially from Iceland and Scandinavian countries; pseudoexfoliation fibers were identified in autopsy tissue specimens of skin, heart, lungs, liver, and cerebral meninges; consistently associated with connective tissue components, i.e., fibroblasts, collagen and elastic fibers, myocardial tissue and heart muscle cell.

Ocular: Gray or white fluffy material deposited in particles, flakes, or sheets on anterior surface of iris, ciliary body, posterior surface of cornea, pupillary margin, lens, and trabecular meshwork; increased pigmentation of trabecular meshwork; zonular dialysis; displaced or dislocated lens; anterior chamber depth asymmetry; preoperative phacodonesis; glaucoma; cataract.

Clinical: None.

Mizuno K, Muroi S. Cycloscopy of pseudo exfoliation. Am J Ophthalmol 1979; 87:513-518.

Schlotzer-Schrehardt U, Maumann GO.A histopathologic study of zonular instability in pseudoexfoliation syndrome. Am J Ophthalmol 1994; 118:730-743.

Schlotzer-Schrehardt UM, et al. Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol 1992; 110: 1752-l756.

Skuta GL, et al. Zonular dialysis during extracapsular cataract extraction in pseudoexfoliation syndrome. Arch Ophthalmol 1987; 105:632-634.

Suzuki R, Kurimoto S. Intraocular muscle function in pseudo exfoliation syndrome. Ophthalmologica 1992; 204: 192-l98.