Morphea (localized scleroderma; circumscribed scleroderma)

General: Localized chronic connective tissue disease of unknown etiology; eti 424b15e ology remains unknown, although there is a possible association with Borrelia burgdorferi infection.

Ocular: Circumscribed plaque like lesions of the eyelid; prevalent in females; onset usually in second to fourth decades of life; onset occasionally associated with trauma, pregnancy, or menopause.

Clinical: Firm skin plaques over entire body, but most frequently on trunk, lower extremities, upper extremities, face, and genitalia; abdominal pain; migraine; generalized joint pain; renal crisis; Raynaud phenomenon; systemic sclerosis; eosinophilia; positive antinuclear factor; increased immunoglobulin (immunoglobulin G [IgG]); seizures; skin sclerosis; alterations in tryptophan metabolism.

Baba FE, et al. Morphea of the eyelids. Ophthalmology 1982; 89:1285-l288.

Ghersetich I, et al. Localized scleroderma. Clin Dermatol 1994; 12:237-242.

Maricq HR. Capillary abnormalities, Raynaud's phenomenon, and systemic sclerosis in patients with localized scleroderma. Arch Dermatol 1992; 128:630-632.

Trevisan G, et al. Borrelia burgdorferi and localized scleroderma. Clin Dermatol 1994; 12:475-479.

West RH, Barnett AJ. Ocular involvement in scleroderma. Br J Ophthalmol 1979; 63: 845-847.

Wigley FM. Clinical aspects of systemic and localized scleroderma. Curr Opin Rheumatol 1994; 6:628-636.